Translating Preclinical Gut-Brain Axis Research into Clinical Trials Using Prebiotic Interventions
Time: 4:00 pm
day: Focus Day Track 4
Details:
- Overview of the gut-brain axis: Emerging work suggests that the gut microbiota and its metabolites play a key role in modulating brain activity and behaviour. One of the key mechanisms by which the gut microbiota influences the brain is via the production of shortchain fatty acids (SCFAs), produced during the microbial fermentation of prebiotic fibre
- How to translate preclinical gut-brain axis research into human clinicals: Most of the gutbrain axis research comes from preclinical (animal) studies, but due to the large variability between the mouse and human microbiota, preclinical observations have not always been replicated in clinical trials
- Finally, I’ll present findings from a 12-week open label parallel group RCT, where participants were randomised into a control group receiving healthy eating advice, or an intervention group receiving healthy eating advice alongside myota’s daily prebiotic supplement. At pre- and post-invention, we assessed gut microbiome profiles, inflammation, and mood, stress, and anxiety scores. This work represents a critical step in progressing gut-brain axis research from preclinical settings, to the more complex and nuanced human state
