Multi-Level Analysis of the Gut–Brain Axis Shows Autism Spectrum Disorder-Associated Molecular & Microbial Profiles
Time: 9:00 am
day: Focus Day Track 1
Details:
- We designed a Bayesian differential abundance algorithm that analyzed 15 studies, 25 datasets and multiple omics levels to identify links between the gut microbiome and autism
- We identified metabolic signatures spanning diet, gut metagenome and host brain transcriptome that that differentiated autistic individuals from age-sex matched neurotypical controls
- The majority of the inferred ASD-associated microbes in the meta-analysis were depleted in the Kang et al FMT study, mirroring the improvement in autistic symptoms 2 years after the intervention
