Understand How an Interventional Strategy of Metabolite Removal is Being Translated into a Clinical Setting

Time: 3:30 pm
day: Day Two – Track B – 2


  • Microbial metabolites have been implicated in many neurological conditions, from neurodevelopmental and behavioral disorders to neurodegenerative diseases
  • Axial, in collaboration with its scientific founder, has established that metabolites derived from the gut microbiome can reach the brain and alter oligodendrocyte maturation, and hence myelination capacity, which can be tied to behavioral changes (Nature, accepted)
  • A resulting interventional strategy of metabolite removal is being translated into a clinical setting; Axial is developing AB-2004, a gut-retained sequestrant molecule, to manage irritability associated with autism. We plan to tell this mechanistic and translational story