Genetically Engineered Microbial Medicines (GEMMs) for the Treatment of Chronic Diseases

Time: 12:00 pm
day: Day Two – Track A – 1

Details:

  • Novome has developed a suite of synthetic biology tools for engineering highly abundant gut commensal microbes
  • Establishing an exclusive niche through rare carbohydrate utilization enables robust and controllable engraftment of GEMMs in the gastrointestina l tract
  • The company’s lead asset is a GEMM designed to treat hyperoxaluria and prevent recurrent kidney stone formation through the breakdown of dietary oxalate
  • A recently completed first-in-human study in healthy volunteers demonstrated safety and tolerability of the therapy as well as platform proof-of-concept that strain engraftment can be precisely controlled by once-daily oral dosing of a prebiotic control molecule

Speakers: